Professionals

The LIVERATION project team

Expected Potential of Pragmatic Clinical Trials

Pragmatic clinical trials hold significant promise for advancing medical research and improving patient care. Unlike traditional randomized controlled trials, pragmatic trials are designed to evaluate interventions in real-world settings, reflecting the diversity and complexity of routine clinical practice.

The expected potential of pragmatic clinical trials lies in their ability to generate evidence that is directly applicable to everyday clinical decision-making. By studying the impact of interventions in diverse patient populations and real-world conditions, pragmatic trials can provide valuable insights into the effectiveness, safety, and cost-effectiveness of treatments. Through the LIVERATION project’s ambitious multicenter clinical trial, we aim to unlock new knowledge that can directly inform liver cancer treatment strategies and ultimately improve patient outcomes.

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This dynamic platform serves as a repository of curated scientific articles, research papers, and resources, all contributing to a deeper understanding of liver cancer treatment and patient care.

Within this Hub, you will find a wealth of evidence, insights, and data from our multicenter clinical trial, shedding light on the impact of additional ablated margins produced by radiofrequency on CRLM and hepatocellular carcinoma.

From peer-reviewed publications to informative sources, the Hub is designed to foster knowledge exchange and promote evidence-based decision-making in liver cancer management. We invite you to explore and immerse yourself in the vast array of resources available here, empowering you to join us in the fight against liver cancer and the pursuit of improved patient outcomes.

Hub of articles

Authors	Title	Journal / Source	Year	Volume	Pages	URL (doi)	Contributors
R. Quesada, A. Moreno, I. Poves, E. Berjano, L. Grande, F. Burdío	The impact of radiofrequency-assisted transection on local hepatic recurrence after resection of colorectal liver metastases	Surgical Oncology	2.017	26	229-235	https://www.sciencedirect.com/science/article/abs/pii/S0960740417300099?via%3Dihub
Villamonte, M., Burdío, F., Sánchez-Velázquez, P., Pérez, M., Martinez, A., & Ielpo, B	New technique to increase resection margins during mini-invasive liver resection: a propensity score-matched study.	Digestive Medicine Research (DMR)	2.022	5	23	https://dmr.amegroups.org/article/view/8255/html
Villamonte, M., Burdío, F., Pueyo, E., Andaluz, A., Moll, X., Berjano, E., ... & Sánchez-Velázquez, P.	The impact of additional margin coagulation with radiofrequency in liver resections with subcentimetric margin: can we improve the oncological results? A propensity score matching study.	European Journal of Surgical Oncology	2.022	48	82-88	https://www.sciencedirect.com/science/article/pii/S0748798321005709
Ourania Koutsiouroumpa, Christos Christogiannis, & Dimitris Mavridis	Introduction to meta-analysis and network meta analysis	Video by University of Ioannina	2.023			https://drive.google.com/file/d/1ZERtqGKC3sie20p_cqhqt6Beei7F_Ups/view
Christos Christogiannis, Ourania Koutsiouroumpa, & Dimitris Mavridis	Introduction to survival analysis	Video by University of Ioannina	2.023			https://drive.google.com/file/d/1sqZv8_Lq8a9Jb2abqGRk9DMnPHxUtrCm/view
Yoshio Masuda, Mark Hao Xuan Yeo, Fernando Burdio, Patricia Sanchez-Velazquez, et al.	Factors affecting overall survival and disease-free survival after surgery for hepatocellular carcinoma: a nomogram-based prognostic model—a Western European multicenter study	Updates in Surgery	2.023			https://doi.org/10.1007/s13304-023-01656-8
Antoniou, S.A., Mavridis, D., Tsokani, S. et al.	Network meta-analysis as a tool in clinical practice guidelines.	Surgical Endoscopy	2.023	37	1-4	https://doi.org/10.1007/s00464-022-09772-z
G Seitidis, S Nikolakopoulos, EA Hennessy, EE Tanner-Smith & D Mavridis	Network Meta-Analysis Techniques for Synthesizing Prevention Science Evidence	Prevention Science	2.022	23	415–424	https://doi.org/10.1007/s11121-021-01289-6
Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., ... & Takeda, F.	The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology.	JNCI: Journal of the National Cancer Institute	1.993	85(5)	365-376	https://doi.org/10.1093/jnci/85.5.365	FAD
Chie, W. C., Blazeby, J. M., Hsiao, C. F., Chiu, H. C., Poon, R. T., Mikoshiba, N., Al-Kadhimi, G., Heaton, N., Calara, J., Collins, P., Caddick, K., Costantini, A., Vilgrain, V., Trinquart, L., Chiang, C., & EORTC Quality of Life Group	International cross-cultural field validation of an European Organization for Research and Treatment of Cancer questionnaire module for patients with primary liver cancer, the European Organization for Research and Treatment of Cancer quality-of-life questionnaire HCC18.	Hepatology (Baltimore, Md.)	2.012	55(4)	1122–1129	https://doi.org/10.1002/hep.24798	FAD
Arditi, C., Eicher, M., Colomer‐Lahiguera, S., Bienvenu, C., Anchisi, S., Betticher, D., ... & Peytremann‐Bridevaux, I.	Patients' experiences with cancer care in Switzerland: Results of a multicentre cross‐sectional survey.	European Journal of Cancer Care	2.022	31(6)	e13705	https://doi.org/10.1111/ecc.13705	FAD
Evans, P., Schuurman, D., Stahlbrost, A., & Vervoort, K. (K. Malmberg, & I. Vaittinen, Ed.).	Living Lab Methodology: Handbook.	U4IoT Consortium	2.017			DOI: 10.5281/zenodo.1146321.	FAD
Kassianos, A.P (Ed.).	Handbook of Quality of Life in Cancer	Springer	2.022			https://doi.org/10.1007/978-3-030-84702-9	FAD
Authors	Title	Journal / Source	Year	Volume	Pages	URL (doi)	Contributors

Professionals

The LIVERATION project team

Expected Potential of Pragmatic Clinical Trials

Hub of articles

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